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KMID : 0369819820120020037
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Jorunal of Korean Pharmaceutical Sciences
1982 Volume.12 No. 2 p.37 ~ p.44
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Pharmaceutical Study on Ketoprofen Lysinate
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이완하/Lee WH
김장배/지웅길/류병태/Kim JB/Jee UK/Rhyu BT
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Abstract
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In order to enhance water solubility, ketoprofen was made as lysine salt, such as acetylsalicylic acid lysine salt, ibuprofen lysine salt and amino acid salt of phenylbutazone. The purpose of this study was to make a comparison between ketoprofen lysine salt in aspects of analgesic, anti-inflammatory, and antipyretic effect. The experimental results were summerized as followings. 1. Ketoprofen lysinate was composed of one molecule of ketoprofen and one molecule of lysine. The product was water soluble and melting point was 92?C∼94?C. 2. Ketoprofen lysinate showed about 2 times stronger analgesic effect than that of ketoprofen while no difference in antipyretic effect was observed. 3. LD50 of ketoprofen lysinate was higher than that of ketoprofen, suggesting ketoprofen lysinate as safer drug. 4. Blood concentration of ketoprofen lysinate was 156μg/ml while the concentration of ketoprofen was 116μg/ml in 30 min., suggesting long acting as well as high blood concentration.
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